HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → alpha-{6(R)-[1(S)-Carboxy-3-phenylpropylamino]-3(R)-isopropyl-5-oxoperhydro-1,4-thiazepin-4-yl}acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | alpha-{6(R)-[1(S)-Ethoxycarbonyl-3-phenylpropylamino]-3(R)-isopropyl-5-oxoperhydro-1,4-thiazepin-4-yl}acetic acid | HCID 18610525 | — |
| Product | alpha-{6(R)-[1(S)-Carboxy-3-phenylpropylamino]-3(R)-isopropyl-5-oxoperhydro-1,4-thiazepin-4-yl}acetic acid | HCID 18610511 | 75.5% |
Reaction Steps
160 mg of α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-3(R)-isopropyl-5-oxoperhydro-1,4-thiazepin-4-yl}acetic acid (prepared as described in Example 28 above) were hydrolyzed with aqueous sodium hydroxide in the same manner as described in Example 5, giving 113 mg of the title compound as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04699905 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-86b4ad5d463543afa68e3403c95c5172 |
| Source note | uspto-grants-1987_10 |