Sodium Hydroxide → HCID 18610512, compound

HRID 256039Notes

Reaction equation

C([O:3][C:4]([C@@H:6]([NH:15][C@H:16]1[CH2:22][S:21][CH2:20][C@@H:19]([CH3:23])[N:18]([CH2:24][C:25]([OH:27])=[O:26])[C:17]1=[O:28])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])C.[OH-].[Na+]>>[C:4]([C@@H:6]([NH:15][C@H:16]1[CH2:22][S:21][CH2:20][C@@H:19]([CH3:23])[N:18]([CH2:24][C:25]([OH:27])=[O:26])[C:17]1=[O:28])[CH2:7][CH2:8][C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1)([OH:5])=[O:3]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18610526HCID 18610526, compound

Product 1

HCID 18610512HCID 18610512, compoundYield 57.1%

Procedure

175 mg of α-{6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-3(R)-methyl-5-oxoperhydro-1,4-thiazepin-4-yl}acetic acid (prepared as described in Example 31 above) was hydrolyzed with aqueous sodium hydroxide in the same manner as described in Example 5, to give 93 mg of the title compound as a powder.

Sources & evidence

ORD record: ord-c1f28dde70c34914a84d863db5a26b9a
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04699905

Reaction notes

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