DL-Phenylalaninol → HCID 18610528, compound

Participants

Reaction Steps

The procedure described in steps (a) to (h) of Example 1 was repeated, except that L-2-amino-3-phenyl-1-propanol was used as the starting material. Two isomers (derived from the asymmetric carbon atom to which the phenethyl group is attached), that is t-butyl α-{3(S)-benzyl-6(R)-[1(R)-ethoxycarbonyl-3-phenylpropylamino]-5-oxoperhydro-1,4-thiazepin-4-yl}acetate (isomer A) and t-butyl α-{3(S)-benzyl-6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxoperhydro-1,4-thiazepin-4-yl}acetate (isomer B) were obtained as oils.

Provenance & Evidence