Sodium Hydroxide → HCID 18610510, compound

HRID 256042Notes

Reaction equation

[CH2:1]([C@@H:8]1[N:14]([CH2:15][C:16]([OH:18])=[O:17])[C:13](=[O:19])[C@@H:12]([NH:20][C@H:21]([C:30]([O:32]CC)=[O:31])[CH2:22][CH2:23][C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)[CH2:11][S:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>>[CH2:1]([C@@H:8]1[N:14]([CH2:15][C:16]([OH:18])=[O:17])[C:13](=[O:19])[C@@H:12]([NH:20][C@H:21]([C:30]([OH:32])=[O:31])[CH2:22][CH2:23][C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH2:11][S:10][CH2:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 18610519HCID 18610519, compound

Product 1

HCID 18610510HCID 18610510, compoundYield 73.3%

Procedure

326 mg of α-{3(S)-benzyl-6(R)-[1(S)-ethoxycarbonyl-3-phenylpropylamino]-5-oxoperhydro-1,4-thiazepin-4-yl}acetic acid were hydrolyzed with aqueous sodium hydroxide in the same manner as described in Example 5, to give 225 mg of the title compound as a powder.

Sources & evidence

ORD record: ord-15bc19a365174087bd29f3b3745801b0
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04699905

Reaction notes

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