Sodium Hydroxide → HCID 20164796, compound

HRID 256046Notes

Reaction equation

HRID 256046 reaction equation
C([O:3][C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=[CH:25][CH:24]=2)[CH2:19][N:18]([CH2:33][C:34]([OH:36])=[O:35])[C:17]1=[O:37])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:5])C.[OH-].[Na+]>>[C:4]([CH:6]([NH:15][CH:16]1[CH2:22][S:21][CH:20]([C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[CH:26]=[CH:25][CH:24]=2)[CH2:19][N:18]([CH2:33][C:34]([OH:36])=[O:35])[C:17]1=[O:37])[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)([OH:5])=[O:3]

Participants

3

Reactant 2

HCID 14798Sodium HydroxideHCID 20164885HCID 20164885, compound

Product 1

HCID 20164796HCID 20164796, compoundYield 98.4%

Procedure

216 mg of α-[6-(1-ethoxycarbonyl-3-phenylpropylamino)-2-(1-naphthyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetic acid prepared as described in Example 37, were mixed with 2 ml of a 1N aqueous solution of sodium hydroxide, and the mixture was stirred for 16 hours at room temperature. A small amount of insolubles was filtered off and the pH of the filtrate was adjusted to a value of 2.0 by adding 1N hydrochloric acid; the resulting powdery compound was collected by filtration and washed with a small amount of water, to yield 201 mg of the title compound.

Workup

  1. filtrationA small amount of insolubles was filtered off
  2. additionby adding 1N hydrochloric acid
  3. filtrationthe resulting powdery compound was collected by filtration
  4. washwashed with a small amount of water

Sources & evidence

ORD record
ord-a05dbe24fdb045379ed9d3259eb8db30
Source dataset
uspto-grants-1987_10
Patent number
US04699905

Reaction notes

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