Trifluoroacetic acid → alpha-[6-(1-Butoxycarbonyl-3-phenylpropylamino)-5-oxo-2-(3-thienyl)perhydro-1,4-thiazepin-4-yl]acetic acid

Participants

Reaction Steps

130 mg of isomer B of t-butyl α-[6-(1-butoxycarbonyl-3-phenylpropylamino)-5-oxo-2-(3-thienyl)perhydro-1,4-thiazepin-4-yl]acetate (prepared as described in Example 45 above) were treated with trifluoroacetic acid by the same procedure as is described in Example 43 to remove the t-butyl group and give the title compound as a crystalline powder, melting at 156° C., in a yield of 70 mg.

Provenance & Evidence