2-(Ethylamino)ethanol → HCID 178464453, compound

HRID 25606Notes

Reaction equation

HRID 25606 reaction equation
FC(F)(F)C(O)=O.[CH3:8][NH:9][C@H:10]1[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20]OS(C)(=O)=O)[CH2:12][CH2:11]1.Cl[C:27]([O:29][C:30]1[CH:35]=[C:34]([F:36])[CH:33]=[C:32]([F:37])[CH:31]=1)=[O:28].[CH2:38]([NH:40][CH2:41][CH2:42][OH:43])[CH3:39]>>[F:37][C:32]1[CH:31]=[C:30]([O:29][C:27](=[O:28])[N:9]([C@H:10]2[CH2:11][CH2:12][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][N:40]([CH2:38][CH3:39])[CH2:41][CH2:42][OH:43])[CH2:14][CH2:15]2)[CH3:8])[CH:35]=[C:34]([F:36])[CH:33]=1

Participants

4

Reactant 3

HCID 80722-(Ethylamino)ethanolHCID 225676833,5-Difluorophenyl chloroformateHCID 178484797HCID 178484797, compound

Product 1

HCID 178464453HCID 178464453, compound

Procedure

In analogy to examples 29.10 and 29.11, trans-Methansulfonic acid 5-(4-methyl amino-cyclohexyl)-pentyl ester-Trifluoroacetic acid salt and 3,5-difluoro-phenyl chloroformate were reacted, followed by treatment with 2-ethylamino-ethanol to give trans-(4-{5-[Ethyl-(2-hydroxy-ethyl)-amino]-pentyl}-cyclohexyl)-methyl-carbamic acid 3,5-difluoro-phenyl ester, MS: 427 (MH+).

Sources & evidence

ORD record
ord-98da67cdf54940479d96e1e53f147d55
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Reaction notes

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