HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → 2-t-Butoxycarbonylamino-1-chloro-1-(2-thienyl)ethane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | Carbamic acid, [2-hydroxy-2-(2-thienyl)ethyl]-, 1,1-dimethylethyl ester | HCID 13854069 | — |
| Product | 2-t-Butoxycarbonylamino-1-chloro-1-(2-thienyl)ethane | HCID 13854070 | — |
Reaction Steps
Following the procedure described in Example 42(b), 15 g of 2-t-butoxycarbonylamino-1-(2-thienyl)ethanol were chlorinated using phosphorus pentachloride to afford 13.6 g of the title product as crystals melting at 40°-43° C. This substance was used for next step without purification because it was decomposed by silica gel column chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04699905 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-d545e62841c642bca6e98f9aa3aecc6d |
| Source note | uspto-grants-1987_10 |