Phosphorus pentachloride → HCID 20164927, compound

HRID 256069Notes

Reaction equation

[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([C:12]1[O:13][CH:14]=[CH:15][CH:16]=1)O)=[O:7])([CH3:4])([CH3:3])[CH3:2].P(Cl)(Cl)(Cl)(Cl)[Cl:18]>>[C:1]([O:5][C:6]([NH:8][CH2:9][CH:10]([Cl:18])[C:12]1[O:13][CH:14]=[CH:15][CH:16]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 24819Phosphorus pentachloride

HCID 13854071HCID 13854071, compound

Product 1

HCID 20164927HCID 20164927, compound

Procedure

Following the procedure described in Example 42(b), 14 g of 2-t-butoxycarbonylamino-1-(2-furyl)ethanol [prepared as described in step (a) above] was treated with phosphorus pentachloride to afford 15 g of the title compound as crystals, melting at 75°-77° C. This substance was used for the next step without purification because it was decomposed by silica gel column chromatography.

Sources & evidence

ORD record: ord-2ed46aece27348c49f3b62f845ef89c9
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04699905

Reaction notes

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