Methylhydrazine → HCID 13854085, compound

Participants

Reaction Steps

Following the procedure described in Example 42(g), 0.85 g of t-butyl α-[2-(2-furyl)-5-oxo-6-phthalimidoperhydro-1,4-thiazepin-4-yl]acetate [prepared as described in step (e) above] was dephthaloylized by treatment with methylhydrazine, to afford a crude product, which was purified by silica gel column chromatography. From the fraction eluted with a 1:1:8 by volume mixture of methanol, cyclohexane and ethyl acetate was obtained 0.45 g of the title compound as crystals, melting at 90°-92° C.

Provenance & Evidence