HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → alpha-[6-(1-Ethoxycarbonyl-3-phenylpropylamino)-2-(2-furyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | t-Butyl alpha-[6-(1-ethoxycarbonyl-3-phenylpropylamino)-2-(2-furyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetate | HCID 20164822 | — |
| Product | alpha-[6-(1-Ethoxycarbonyl-3-phenylpropylamino)-2-(2-furyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetic acid | HCID 20164816 | — |
Reaction Steps
Following the procedure described in Example 43, 270 mg of isomer B of t-butyl α-[6-(1-ethoxycarbonyl-3-phenylpropylamino)-2-(2-furyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetate [prepared as described in Example 56(g)] were de-t-butylated using trifluoroacetic acid, to afford 180 mg of the title compound as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04699905 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-1801f2c76410447d91f33d49b6161e21 |
| Source note | uspto-grants-1987_10 |