HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → alpha-[6-(1-Butoxycarbonyl-3-phenylpropylamino)-2-(2-furyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | t-Butyl alpha-[6-(1-butoxycarbonyl-3-phenylpropylamino)-2-(2-furyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetate | HCID 20164867 | — |
| Product | alpha-[6-(1-Butoxycarbonyl-3-phenylpropylamino)-2-(2-furyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetic acid | HCID 20164797 | — |
Reaction Steps
Following the procedure described in Example 43, 0.15 g of isomer B of t-butyl α-[6-(1-butoxycarbonyl-3-phenylpropylamino)-2-(2-furyl)-5-oxoperhydro-1,4-thiazepin-4-yl]acetate (obtained as described in Example 59) was de-t-butyrated using trifluoroacetic acid, to afford 95 mg of the title compound as a powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04699905 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-e321180556854fcfbfe52849fecd820d |
| Source note | uspto-grants-1987_10 |