Stearyl Alcohol → HCID 20165240, compound

HRID 256103Notes

Reaction equation

HRID 256103 reaction equation
[CH:1]1([C:7]2[CH:8]=[C:9]([CH2:15][CH2:16][C:17]([O:19][CH3:20])=[O:18])[CH:10]=[C:11]([CH3:14])[C:12]=2[OH:13])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:21](O)[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37]C.[NH2-].[Li+]>>[CH:1]1([C:7]2[CH:8]=[C:9]([CH2:15][CH2:16][C:17]([O:19][CH2:20][CH2:37][CH2:36][CH2:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH3:21])=[O:18])[CH:10]=[C:11]([CH3:14])[C:12]=2[OH:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 3

HCID 8221Stearyl AlcoholHCID 24532Lithium amideHCID 20165245HCID 20165245, compound

Product 1

HCID 20165240HCID 20165240, compound

Conditions

Temperature
150 °C

Procedure

27.6 g of methyl 3-(3-cyclohexyl-4-hydroxy-5-methylphenyl)propionate and 27.1 g of octadecanol are heated, under nitrogen, to 80° C. as described in Example 2. After the addition of 0.1 g of lithium amide, the reaction mixture is heated for 10 hours at 150° C. The methanol forming is continuously distilled off. The yield is 30.2 g of crude product which is in the form of a yellowish oil and can be purified by column chromatography.

Workup

  1. distillationThe methanol forming is continuously distilled off
  2. customcan be purified by column chromatography

Sources & evidence

ORD record
ord-bbd89ef93b79492f99ebda594f38a823
Source dataset
uspto-grants-1987_10
Patent number
US04699939

Reaction notes

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