Sodium Hydroxide → HCID 23704779, compound

HRID 256110Notes

Reaction equation

HRID 256110 reaction equation
[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([CH:12]2[NH:16][C:15]([CH:18]([CH3:20])[CH3:19])([CH3:17])[C:14](=[O:21])[NH:13]2)=[C:7]([CH:11]=1)[C:8]([OH:10])=[O:9])[CH3:2].[OH-].[Na+:23]>CO>[CH2:1]([C:3]1[CH:4]=[N:5][C:6]([CH:12]2[NH:16][C:15]([CH:18]([CH3:20])[CH3:19])([CH3:17])[C:14](=[O:21])[NH:13]2)=[C:7]([CH:11]=1)[C:8]([O-:10])=[O:9])[CH3:2].[Na+:23]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 13752317HCID 13752317, compound

Product 1

HCID 23704779HCID 23704779, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To 1.0 g 5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolidinyl)nicotinic acid is added a solution of 0.1498 g sodium hydroxide in 20 mL absolute methanol. The mixture is stirred under nitrogen at room temperature overnight. The solvent is removed to give a solid which is dried in a vacuum oven at 60° C. for two days. The thus-formed sodium 5-ethyl-2-(4-isopropyl-4-methyl-5-oxo-2-imidazolidinyl)nicotinate darkens at 230° C. and decomposes at 247°-250° C.

Workup

  1. customThe solvent is removed
  2. customto give a solid which
  3. customis dried in a vacuum oven at 60° C. for two days
  4. customdarkens at 230° C.
  5. customdecomposes at 247°-250° C.

Sources & evidence

ORD record
ord-3ffe97c559a74131b5ef54999850f6a8
Source dataset
uspto-grants-1987_10
Patent number
US04701208

Reaction notes

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