反应详情

10 g of 2-picoline and 25 g of 4-methoxyphenacyl bromide in 35 ml of ethanol were refluxed for 18 hours. The reaction solution was concentrated under reduced pressure to give a solid, which was dissolved in 350 ml of water. After the aqueous solution was extracted with three 35 ml portions of ether, 35 g of sodium bicarbonate was added to the aqueous solution and was refluxed two hours. The cooled reaction mixture was filtered to give 20 g of product.

1. concentrationThe reaction solution was concentrated under reduced pressure
2. customto give a solid, which
3. extractionAfter the aqueous solution was extracted with three 35 ml portions of ether, 35 g of sodium bicarbonate
4. additionwas added to the aqueous solution
5. temperaturewas refluxed two hours
6. customThe cooled reaction mixture
7. filtrationwas filtered