反应详情

To a solution of 1.0 g (0.0055 mole) of 4-hydroxymethyl-2,3,5,6-tetrafluoropyridine (from Example 5) in 50 ml of ethanol was added 0.2 g (0.004 mole) of hydrazine hydrate. This mixture was stirred for approximately twenty-four hours during which a white precipitate formed. The reaction mixture was filtered, and the filtrate was concentrated by evaporating the solvent under reduced pressure. Water and ether were added to this residue. The ether layer was separated, dried, and the solvent evaporated, leaving a yellow solid, (4-hydroxymethyl-2,3,5-trifluoropyridin-6-yl)hydrazine. The structure and nmr data are set forth in Table 1C.

1. customformed
2. filtrationThe reaction mixture was filtered
3. concentrationthe filtrate was concentrated
4. customby evaporating the solvent under reduced pressure
5. additionWater and ether were added to this residue
6. customThe ether layer was separated
7. customdried
8. customthe solvent evaporated