反应详情

A mixture of 1.0 g (0.0055 mole) of 4-hydroxymethyl-2,3,5,6-tetrafluoropyridine (from Example 5) and 0.23 g (0.0050 mole) of dimethylamine in 25 ml of ethanol was refluxed for approximately twenty hours. The reaction mixture was cooled and was poured into water. This mixture was extracted with diethyl ether. The extract was dried over anhydrous magnesium sulfate, filtered, and the solvent evaporated under reduced pressure, yielding 0.9 g of 2-dimethylamino-4-hydroxymethyl-3,5,6-trifluoropyridine as a yellow oil. The structure and nmr spectra are set forth in Table 1C below.

1. temperaturewas refluxed for approximately twenty hours
2. temperatureThe reaction mixture was cooled
3. extractionThis mixture was extracted with diethyl ether
4. dry with materialThe extract was dried over anhydrous magnesium sulfate
5. filtrationfiltered
6. customthe solvent evaporated under reduced pressure