3,5-Dichloro-2,6-difluoro4-hydroxymethylpyridine → HCID 86741838, compound

HRID 256168Notes

Reaction equation

HRID 256168 reaction equation
[Cl:1][C:2]1[C:3]([F:12])=[N:4][C:5]([F:11])=[C:6]([Cl:10])[C:7]=1[CH2:8][OH:9].[Cl:13][C:14]([C:24]([F:27])([F:26])[F:25])=[CH:15][C@@H:16]1[C@H:18]([C:19](Cl)=[O:20])[C:17]1([CH3:23])[CH3:22]>>[Cl:13][C:14]([C:24]([F:25])([F:26])[F:27])=[CH:15][C@@H:16]1[C@H:18]([C:19]([O:9][CH2:8][C:7]2[C:2]([Cl:1])=[C:3]([F:12])[N:4]=[C:5]([F:11])[C:6]=2[Cl:10])=[O:20])[C:17]1([CH3:23])[CH3:22]

Participants

3

Reactant 2

HCID 139851663,5-Dichloro-2,6-difluoro4-hydroxymethylpyridineHCID 86737382cis-3-(2-Chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarbonyl chloride

Product 1

HCID 86741838HCID 86741838, compound

Procedure

By The method of Example 2, 0.6 (0.002 mole) of 3,5-dichloro2,6-difluoro-4-hydroxymethylpyridine (Example 15) was reacted with 0.61 g (0.002 mole) of cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarbonyl chloride to produce, after purification using the Chromatotron, 0.5 g of (3,5-dichloro-2,6-difluoropyridin-4-yl)methyl cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate as a clear, white liquid, compound 21 in the Tables below.

Workup

  1. customto produce
  2. customafter purification

Sources & evidence

ORD record
ord-1170f5af2a1647fb8cbd364fcdf8569d
Source dataset
uspto-grants-1987_10
Patent number
US04701464

Reaction notes

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