HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → N-(3-formylphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | N-[3-(1,3-dioxolan-2-yl)phenyl]acetamide | HCID 13987600 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-(3-formylphenyl)acetamide | HCID 256849 | 100.6% |
Reaction Steps
A solution of N-[3-(1,3-dioxolan-2-yl)phenyl]acetamide (50.0 g, 0.24 mole) and p-toluenesulfonic acid (1.0 g) in acetone (750 mL) was stirred at room temperature for 72 hours. The solution was filtered through a pad of neutral alumina and concentrated in vacuo to afford N-(3-formylphenyl)acetamide (39.4 g, 100%), mp 68°-70° C., used without further purification below.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04701459 |
| Source dataset | uspto-grants-1987_10 |
| ORD ID | ord-2a1da0083d5e4beb8dfc71136665e958 |
| Source note | uspto-grants-1987_10 |