Ethylene Glycol → HCID 13588848, compound

Participants

Reaction Steps

In a 500 mL rb flask, 200 mL cyclohexane, 50 mL benzene, 15 g.(0.242 mole) ethylene glycol, 1.5 g p-toluene-sulfonic acid and 19 g (0.049 mole) of 1-(3,4-dimethoxyphenyl)-2-nitro-7-(4-methylphenyl)-5-heptanone were combined and refluxed 24 hours with a Dean-Stark trap. The cooled reaction mixture was poured into cold, sat'd. NaHCO3 and extracted with three 200 mL portions of ethyl acetate. The organic Layer was dried over MgSO4, filtered and concentrated. The residue was triturated with ether and ethyl acetate to give some solid (1.5 g) of mp 89°-91° C.

Provenance & Evidence