2-(Ethylamino)ethanol → HCID 178464457, compound

HRID 25625Notes

Reaction equation

HRID 25625 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([O:6][C:7]([N:9]([CH3:25])[C@H:10]2[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19]OS(C)(=O)=O)[CH2:12][CH2:11]2)=[O:8])=[CH:4][CH:3]=1.[CH2:28]([NH:30][CH2:31][CH2:32][OH:33])[CH3:29]>>[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([O:6][C:7](=[O:8])[N:9]([C@H:10]2[CH2:15][CH2:14][C@H:13]([CH2:16][CH2:17][CH2:18][CH2:19][N:30]([CH2:28][CH3:29])[CH2:31][CH2:32][OH:33])[CH2:12][CH2:11]2)[CH3:25])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 80722-(Ethylamino)ethanolHCID 178485963HCID 178485963, compound

Product 1

HCID 178464457HCID 178464457, compound

Procedure

In analogy to examples 31.6, trans-Methanesulfonic acid 4-{4-[(4-chloro-phenoxycarbonyl)-methyl-amino]-cyclohexyl}-butyl ester was treated with 2-ethylamino-ethanol to give trans-(4-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-methyl-carbamic acid 4-chloro-phenyl ester, MS: 411 (MH+, 1Cl).

Sources & evidence

ORD record
ord-2daaa3b43345406bb478623a4c424ace
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Reaction notes

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