反应详情

温度

0 °C

2,2,5,5-Tetramethyl-1-cyclopentylmethanol is dissolved in benzene and stirred at 0° C. under argon. A solution of phosphorus tribromide in benzene is added and the mixture is stirred for 2 hours and then heated to 60° C. for 4 hours. The mixture is cooled, poured into ice and extracted with ether. The organic layer is washed with saturated NaHCO3, dried over MgSO4 and evaporated to yield 2,2,5,5-Tetramethyl-1-cyclopentylmethyl bromide.

1. stirringthe mixture is stirred for 2 hours
2. temperatureheated to 60° C. for 4 hours
3. temperatureThe mixture is cooled
4. additionpoured into ice
5. extractionextracted with ether
6. washThe organic layer is washed with saturated NaHCO3
7. dry with materialdried over MgSO4
8. customevaporated