2-(Ethylamino)ethanol → HCID 178464458, compound

HRID 25627Notes

Reaction equation

HRID 25627 reaction equation
[CH3:1][NH:2][C@H:3]1[CH2:8][CH2:7][C@H:6]([CH2:9][CH2:10][CH2:11][CH2:12]OS(C)(=O)=O)[CH2:5][CH2:4]1.FC(F)(F)C(O)=O.[F:25][C:26]([F:38])([F:37])[C:27]1[CH:32]=[CH:31][C:30]([S:33](Cl)(=[O:35])=[O:34])=[CH:29][CH:28]=1.[CH2:39]([NH:41][CH2:42][CH2:43][OH:44])[CH3:40]>>[CH2:39]([N:41]([CH2:42][CH2:43][OH:44])[CH2:12][CH2:11][CH2:10][CH2:9][C@H:6]1[CH2:5][CH2:4][C@H:3]([N:2]([CH3:1])[S:33]([C:30]2[CH:31]=[CH:32][C:27]([C:26]([F:38])([F:37])[F:25])=[CH:28][CH:29]=2)(=[O:35])=[O:34])[CH2:8][CH2:7]1)[CH3:40]

Participants

4

Reactant 3

HCID 80722-(Ethylamino)ethanolHCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 178484801HCID 178484801, compound

Product 1

HCID 178464458HCID 178464458, compound

Procedure

In analogy to examples 31.5 and 31.6, trans-Methanesulfonic acid 4-(4-methylamino-cyclohexyl)-butyl ester-trifluoro-acetic acid and 4-trifluoromethyl-phenyl-sulfonylchloride were reacted, followed by treatment with 2-ethylamino-ethanol to give trans-N-(4-{4-[Ethyl-(2-hydroxy-ethyl)-amino]-butyl}-cyclohexyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide, MS: 465 (MH+).

Sources & evidence

ORD record
ord-0fdc07d87a324fbcb5294050acc62ef3
Source dataset
uspto-grants-2005_02
Patent number
US06858651B2

Reaction notes

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