Sodium Bromide → 3-Methyl-4,5-dihydro-1H-pyrazole

HRID 256292Notes

Reaction equation

HRID 256292 reaction equation
[CH3:1][C:2]1[CH2:6][CH2:5][NH:4][N:3]=1.[Na+].[Br-]>CO>[CH3:1][C:2]1[CH2:6][CH2:5][NH:4][N:3]=1.[CH3:1][C:2]1[CH:6]=[CH:5][NH:4][N:3]=1

Participants

5

Reactant 2

HCID 253881Sodium BromideHCID 5580923-Methyl-4,5-dihydro-1H-pyrazole2×

Product 2

HCID 5580923-Methyl-4,5-dihydro-1H-pyrazoleHCID 178428694HCID 178428694, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 100 g of 3-methyl-2-pyrazoline and 64 g of NaBr in 3,000 g of methanol was electrolysed with 2 F/mol of 3-methyl-2-pyrazoline at a current density of 6.8 A/dm2 at a temperature of 20° C. Customary working up of the electrolysed mixture and fractional distillation gave 24.5 g of 3-methyl-2-pyrazoline and 29.5 g of 3-methylpyrazole (boiling point 127°-131° C./98 mbar). This corresponds to a conversion of 75%, a yield of 30% and a selectivity of 40%.

Workup

  1. customat a temperature of 20° C
  2. distillationCustomary working up of the electrolysed mixture and fractional distillation

Sources & evidence

ORD record
ord-1daa6fcf43364b1785444f3d50ae8eee
Source dataset
uspto-grants-1987_10
Patent number
US04702803

Reaction notes

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