HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 256324Generated: October 26, 2026
Triethyl phosphite → Diethyl 4-phenylbutylphosphonate
https://huagongshe.com/reaction/256324
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethyl phosphite | HCID 31215 | — |
| Reactant | (4-Chlorobutyl)benzene | HCID 78543 | — |
| Product | Diethyl 4-phenylbutylphosphonate | HCID 13102400 | 84.1% |
Reaction Steps
A mixture of 4-phenylbutyl chloride (8.0 g, 47.5 mmole) and triethylphosphite (15.0 ml, 72 mmole) was heated at reflux (bath temperature 185° C.) under argon for 41.5 hours. Distillation of the mixture gave pure diethyl (4-phenylbutyl)phosphonate (10.8 g, 84%) as a colorless liquid, b.p. 152°-154° C. (1.0 mmHg). TLC (EtOAc) single spot Rf =0.55.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04703043 |
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| Source dataset | uspto-grants-1987_10 |
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| ORD ID | ord-b56b5521a0d0472694e4d02edfc34ec4 |
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| Source note | uspto-grants-1987_10 |
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