反应详情

A mixture of 5.3 g (0.019 mole) of 3-(acetylamino)N-1H-tetrazol-5-yl-2-benzofurancarboxamide in 50 ml of ethanol plus 50 ml of concentrated (12.0 M) hydrochloric acid is stirred at reflux for two hours. The reaction mixture is cooled in ice to precipitate 3-amino-N-1H-tetrazol-5-yl-2-benzofurancarboxamide. The precipitate is filtered, washed with 50% aqueous ethanol, and recrystallized from aqueous 2-methoxyethanol to yield 2.4 g (53% yield) of the analytically pure 3-amino-N-1H-tetrazol-5-yl-2-benzofurancarboxamide, mp 275° C.-dec.

1. concentrationof concentrated (12.0 M) hydrochloric acid
2. temperatureat reflux for two hours
3. temperatureThe reaction mixture is cooled in ice
4. customto precipitate 3-amino-N-1H-tetrazol-5-yl-2-benzofurancarboxamide
5. filtrationThe precipitate is filtered
6. washwashed with 50% aqueous ethanol
7. customrecrystallized from aqueous 2-methoxyethanol