反应详情

A solution of 1-(2-bromoacetyl)-2,2-dimethyl-4-imidazolidinone (1.9 g) in 8.8 ml of benzylamine was stirred at room temperature for 4 hours. The excess of benzylamine was removed under reduced pressure (about 5 mmHg) at 80° C. The residue was taken up with ethyl acetate and the precipitate filtered off. The filtrate was evaporated and the residue was chromatographed on a silica gel column by eluting with dichloromethane/methanol 7:3. The selected fractions were collected and evaporated. Trituration of the residue with ether gave 1 g of the title compound as a white powder, m.p. 131°-132° C.

1. customThe excess of benzylamine was removed under reduced pressure (about 5 mmHg) at 80° C
2. filtrationthe precipitate filtered off
3. customThe filtrate was evaporated
4. customthe residue was chromatographed on a silica gel column
5. washby eluting with dichloromethane/methanol 7:3
6. customThe selected fractions were collected
7. customevaporated