反应详情

(1) To a solution of glycylglycinamide acetate (10 g) in methanol (250 ml) and acetone (125 ml), Amberlite IRA-68 resin (20 g) (from Rohm & Haas, Philadelphia, USA) was added. Amberlite is a registered trade mark and IRA-68 is a weakly basic resin. The suspension was stirred at room temperature for 1 hour, then resin was filtered off and the solution was evaporated under reduced pressure. The residue was suspended in refluxing acetone (250 ml) and methanol was added to obtain a clear solution, which was refluxed for 2 hours. Evaporation and trituration of the residue with acetone gave 2,2-dimethyl-5-oxo-1-imidazolidineacetamide (6.85 g).

1. filtrationresin was filtered off
2. customthe solution was evaporated under reduced pressure
3. temperaturein refluxing acetone (250 ml) and methanol
4. additionwas added
5. customto obtain a clear solution, which
6. temperaturewas refluxed for 2 hours
7. customEvaporation and trituration of the residue with acetone