Chloroacetyl chloride → 3-(2-Chloroacetyl)-2,2-dimethyl-5-oxo-1-imidazolidineacetamide

HRID 256361Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 256361
[CH3:1][C:2]1([CH3:12])[NH:6][CH2:5][C:4](=[O:7])[N:3]1[CH2:8][C:9]([NH2:11])=[O:10].C(=O)([O-])O.[Na+].[Cl:18][CH2:19][C:20](Cl)=[O:21]>>[Cl:18][CH2:19][C:20]([N:6]1[CH2:5][C:4](=[O:7])[N:3]([CH2:8][C:9]([NH2:11])=[O:10])[C:2]1([CH3:12])[CH3:1])=[O:21]

Komponenten

4

Edukt 3

HCID 6577Chloroacetyl chlorideHCID 516892Sodium Bicarbonate2×HCID 201554662,2-Dimethyl-5-oxo-1-imidazolidineacetamide

Produkt 1

HCID 201637523-(2-Chloroacetyl)-2,2-dimethyl-5-oxo-1-imidazolidineacetamide

Versuchsvorschrift

An ice cold solution of 2,2-dimethyl-5-oxo-1-imidazolidineacetamide (1 g) in 20 ml of saturated solution of sodium hydrogen carbonate was added with an additional 2 g of sodium hydrogen carbonate and treated dropwise with chloroacetyl chloride (3 ml). After 30 minutes of stirring the precipitate was collected and crystallized from methanol, to give 3-(2-chloroacetyl)-2,2-dimethyl-5-oxo-1-imidazolidineacetamide (0.53 g) as a white powder m.p. 214°-216° C.

Aufarbeitung

  1. customwas collected
  2. customcrystallized from methanol

Quellen und Nachweise

ORD-Eintrag
ord-5b2cbcf1df1e412fadcfcfc9f8b10ec6
Quelldatensatz
uspto-grants-1987_10
Patentnummer
US04703054

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