Ammonia → 3-(2-Aminoacetyl)-2,2-dimethyl-5-oxo-1-imidazolidine acetamide hydrochloride

HRID 256362Notes

Reaction equation

HRID 256362 reaction equation
[Cl:1][CH2:2][C:3]([N:5]1[CH2:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([NH2:14])=[O:13])[C:6]1([CH3:16])[CH3:15])=[O:4].[NH3:17]>C(O)C>[ClH:1].[NH2:17][CH2:2][C:3]([N:5]1[CH2:9][C:8](=[O:10])[N:7]([CH2:11][C:12]([NH2:14])=[O:13])[C:6]1([CH3:16])[CH3:15])=[O:4]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 201637523-(2-Chloroacetyl)-2,2-dimethyl-5-oxo-1-imidazolidineacetamide

Product 1

HCID 201637053-(2-Aminoacetyl)-2,2-dimethyl-5-oxo-1-imidazolidine acetamide hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A suspension of 3-(2-chloroacetyl)-2,2-dimethyl-5-oxo-1-imidazolidineacetamide (0.48 g) in 33% ammonia solution (6 ml) was stirred at room temperature for 90 minutes. The clear solution obtained was diluted with dry ethanol (80 ml) and evaporated under reduced pressure. The residue was crystallized from water/acetone to afford 3-(2-aminoacetyl)-2,2-dimethyl-5-oxo-1-imidazolidine acetamide hydrochloride as a white powder, m.p. 292° C. decomp.

Workup

  1. customThe clear solution obtained
  2. customevaporated under reduced pressure
  3. customThe residue was crystallized from water/acetone

Sources & evidence

ORD record
ord-0eab3dbadc7548d7ba5172fcd67d59c9
Source dataset
uspto-grants-1987_10
Patent number
US04703054

Reaction notes

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