反应详情

To a stirred solution of 4-hydroxy-2-oxo-1-pyrrolidine acetic acid (3.18 g) and 2,2-dimethyl-5-oxo-1-imidazolidineacetamide (3.5 g) in 100 ml of dimethylformamide at room temperature, 4.12 g of DCC were added at once. After 5 hours the solvent was evaporated under vacuum and the residue was suspended in 50 ml of stirred water. After 10 minutes the solid was filtered off and the water evaporated under reduced pressure. The residue was triturated with isopropanol and collected, affording the title product as a white powder m.p. 248°-250° C. (decomp).

1. customAfter 5 hours the solvent was evaporated under vacuum
2. filtrationAfter 10 minutes the solid was filtered off
3. customthe water evaporated under reduced pressure
4. customThe residue was triturated with isopropanol
5. customcollected