反应详情

温度

110 °C

A mixture of ethyl 2-oxo-1-pyrrolidineacetate (7 g) and 1-(2-aminoacetyl)-2-isopropyl-4-imidazolidinone (4 g) was heated at 110° C. for 8 hours. After cooling the oily residue was chromatographed on a silica gel column (eluant dichloromethane/methanol 9:1). The selected fractions were collected, evaporated under vacuum and the residue was triturated with diisopropyl ether to yield 2.6 g of the title compound, m.p. 104°-106° C. Mass spectrum (E.I., 70 eV, 1.5 mA), m/z=310 (M.+), 267 (M.+ --C3H7).

1. temperatureAfter cooling the oily residue
2. customwas chromatographed on a silica gel column (eluant dichloromethane/methanol 9:1)
3. customThe selected fractions were collected
4. customevaporated under vacuum
5. customthe residue was triturated with diisopropyl ether