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HRID25638

反应详情

EQUATION

反应方程式

HRID 25638 的结构方程式

REACTANTS

反应物

1
结构：CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](C#CCO)CC1
HCID178486040

未命名化合物

PRODUCTS

生成物

1
结构：CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](CCCO)CC1
HCID178486042

未命名化合物

收率 101.4%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：O.[O]=[Pt]=[O]
催化剂HCID11139377

未命名化合物

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

A suspension of 3.4 g (12.72 mmol) of trans-[4-(3-Hydroxy-prop-1-ynyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester in 125 ml ethanol and 810 mg of PtO2.H2O was hydrogenated (1 atm) for 7 h. The reaction was filtered (Celite) and evaporated to give 3.5 g (quantitative) of trans-[4-(3-Hydroxy-propyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester, MS: 271 (MH).

WORKUP

后处理

  1. customfor 7 h
  2. filtrationThe reaction was filtered (Celite)
  3. customevaporated