Ammonia → HCID 178509021, compound

HRID 256468Notes

Reaction equation

[OH:1][C:2]1[N:7]=[C:6](Cl)[C:5]([F:9])=[CH:4][N:3]=1.[NH3:10]>>[F:9][C:5]1[C:6]([NH2:10])=[N:7][C:2](=[O:1])[NH:3][CH:4]=1

Participants

Reactant 2

HCID 222Ammonia

HCID 178517766HCID 178517766, compound

Product 1

HCID 178509021HCID 178509021, compound

Procedure

5-fluorocytosine is prepared by reacting 2,5-difluoro-4-chloro-pyrimidine with a proton acid in the presence of water to yield 2-hydroxy-4-chloro-5-fluoropyrimidine and reacting the 2-hydroxy-4-chloro-5-fluoropyrimidine with ammonia to yield 5-fluoro-cytosine.

Sources & evidence

ORD record: ord-31baa4498483481db5356ddb71fc180b
Source dataset: uspto-grants-1987_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04703121

Reaction notes

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