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HRID25647

反应详情

EQUATION

反应方程式

HRID 25647 的结构方程式

REACTANTS

反应物

2
结构：CN(C(=O)OC(C)(C)C)[C@H]1CC[C@H](C#CCCCCl)CC1
HCID178486028

未命名化合物

结构：C[NH2+][C@H]1CC[C@H](C#CCCCCl)CC1.O=C([O-])C(F)(F)F
HCID178486209

未命名化合物

PRODUCTS

生成物

1
结构：CN[C@H]1CC[C@H](C#CCCCCl)CC1
HCID178484792

未命名化合物

PROCEDURE

实验过程

In analogy to example 32.1, trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-carbamic acid tert-butyl ester was converted to trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-ammonium trifluoroacetate. The compound was purified by dissolving the salt in water, washing it with Et2O (3×). The water phase was adjusted to pH 8 (with aqueous saturated NaHCO3) and extracted with EtOAc (3×) to give trans-[4-(5-Chloro-pent-1-ynyl)-cyclohexyl]-methyl-amine, MS: 314 (MH+, 1Cl).

WORKUP

后处理

  1. customThe compound was purified
  2. dissolutionby dissolving the salt in water
  3. washwashing it with Et2O (3×)
  4. extractionextracted with EtOAc (3×)