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4-Hydroxybiphenyl → 4-(8-Hydroxyoctyl)oxybiphenyl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Hydroxybiphenyl | HCID 7103 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 1-Octanol, 8-bromo- | HCID 162607 | — |
| 触媒 | Trioctylmethylammonium chloride | HCID 21218 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 4-(8-Hydroxyoctyl)oxybiphenyl | HCID 13959115 | 65.4% |
反応手順
A mixture of 37.8 g of 8-bromo-1-octanol, 30.77 g of 4-phenylphenol, 8.31 g of sodium hydroxide and 34 g of N--methyl-N,N--dioctyl-1-octanaminium chloride in 100 ml of water and 175 ml of tetrahydrofuran was refluxed for 17 hours. The tetrahydrofuran was removed and the residue extracted with warm chloroform. The chloroform extract was washed with water, dried and the solvent removed. The residue was recrystallized from methanol, giving 35.26 g of the desired compound as a white solid, mp 101°-103° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04703130 |
| 出典データセット | uspto-grants-1987_10 |
| ORD ID | ord-ef4b0c88312a4ec6908e3248d17efc7c |
| 出典メモ | uspto-grants-1987_10 |