Acetic Anhydride → HCID 178474036, compound

HRID 256518Notes

Reaction equation

HRID 256518 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][C:6]([OH:14])=[C:7]([CH3:13])[C:8]=2[CH3:12])[N:3]=1.[C:15](OC(=O)C)(=[O:17])[CH3:16]>>[NH:1]([C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][C:6]([OH:14])=[C:7]([CH3:13])[C:8]=2[CH3:12])[N:3]=1)[C:15]([CH3:16])=[O:17]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 178431752HCID 178431752, compound

Product 1

HCID 178474036HCID 178474036, compoundYield 37%

Procedure

142 g (0.75 mol) of 2-amino-7-hydroxy-5,6-dimethyl-1,8-naphthyridine and 640 ml of acetic anhydride are boiled under reflux for 30 minutes. After the mixture has been cooled, the product is filtered off and purified by stirring with CH2Cl2 and methanol. There is obtained 64.1 g (37%) of a gray solid.

Workup

  1. temperatureunder reflux for 30 minutes
  2. temperatureAfter the mixture has been cooled
  3. filtrationthe product is filtered off
  4. custompurified

Sources & evidence

ORD record
ord-f8ba5d9a673041c3955ff600915a0585
Source dataset
uspto-grants-1993_11
Patent number
US05258356

Reaction notes

Loading…