Methanesulfonic Acid → HCID 19785214, compound

Participants

Reaction Steps

A mixture of N-(2-hydroxy-2-phenylethyl)-N-methyl-2-(1-phenylsulphonyl-3-pyrrolyl)ethylamine (5.5 g), trifluoroacetic acid (200 ml) and methanesulphonic acid (2.13 g) was refluxed for 2.5 hours. After evaporating to dryness, water then 0.880 ammonia were added and the product was extracted into dichloromethane. The extracts were washed with water, dried and evaporated to give an oil. The oil was purified by chromatography on silica, eluting with chloroform then increasing amounts of methanol (1-5%) in chloroform to give the title product as a solid, m.p. 115°-116° C. (ethanol).

Provenance & Evidence