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Pyridine → N-(4-amino-5-pyrimidinyl)-4-fluorobenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pyridine | HCID 1049 | — |
| 反応物 | Dimethylformamide | HCID 6228 | — |
| 反応物 | 4-Fluorobenzoyl chloride | HCID 67879 | — |
| 反応物 | 4,5-Diaminopyrimidine | HCID 83703 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | N-(4-amino-5-pyrimidinyl)-4-fluorobenzamide | HCID 19785297 | 70% |
反応手順
To a stirred mixture of 20.2 parts of 4,5-pyrimidinediamine, 40 parts of pyridine and 144 parts of N,N-dimethylformamide was added dropwise a solution of 24.2 parts of 4-fluorobenzoyl chloride in 36 parts of N,N-dimethylformamide at 10° C. Upon completion, stirring was continued for 30 minutes at room temperature. 600 Parts of water were added. The product was filtered off and dried, yielding 30 parts (70%) of N-(4-amino-5-pyrimidinyl)-4-fluorobenzamide (interm. 11).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05258380 |
| 出典データセット | uspto-grants-1993_11 |
| ORD ID | ord-296f035cade34f5380d88441c6b5ee95 |
| 出典メモ | uspto-grants-1993_11 |