HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → HCID 178505787, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Carbon Disulfide | HCID 6348 | — |
| Reactant | N4-[(4-fluorophenyl)methyl]-4,5-pyrimidinediamine | HCID 70462412 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178505787 | HCID 178505787 | 78.9% |
Reaction Steps
A mixture of 8.72 parts of N4 -[(4-fluorophenyl)methyl]-4,5-pyrimidinediamine, 63 parts of carbon disulfide and 45 parts of N,N-dimethylformamide was stirred for 3 hours at reflux temperature. After cooling, the reaction mixture was poured into water. The precipitated product was filtered off and dried, yielding 10.1 parts (78.9%) of 9-[(4-fluorophenyl)methyl]-9H-purine-8-thiol (interm. 24).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05258380 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-c9729cdcae564bebb05617eea17e883d |
| Source note | uspto-grants-1993_11 |