反应详情

A mixture of 40 parts of methyl 3-methyl-4-[(phenylmethyl)amino]-1-piperidinecarboxylate and 160 parts of methanol was hydrogenated at normal pressure and at room temperature with 2 parts of palladium-on-charcoal catalyst 10%. After the calculated amount of hydrogen was taken up, the catalyst was filtered off and the filtrate was evaporated to dry. The residue was distilled (bp. 80° C. at 0.1 mm. pressure). The distillate was further purified by gas-chromatography (at 215° C. and at 10 lbs/sq. inch), yielding 8.6 parts of methyl 4-amino-3-methyl-1-piperidinecarboxylate (interm. 27)

1. filtrationthe catalyst was filtered off
2. customthe filtrate was evaporated
3. customto dry
4. distillationThe residue was distilled (bp. 80° C. at 0.1 mm. pressure)
5. distillationThe distillate was further purified by gas-chromatography (at 215° C. and at 10 lbs/sq. inch)