Potassium Hydroxide → HCID 19785561, compound

Participants

Reaction Steps

Ethyl 4-(1-(2,4'-difluoro-4-biphenylyl)ethyl)-2-methylamino-5-thiazolecarboxylate (1.00 g, 2.48 mmole) was dissolved in methanol (20 ml). After adding a solution of potassium hydroxide (420 mg, 7.49 mmole) in water (4 ml), the mixture was heated under reflux for 5 hours. The reaction mixture was concentrated under reduced pressure, and the residue was diluted with water and washed with ether. The water layer was acidified to about pH 4 with 1chloric acid and extracted with ethyl acetate. The organic layer was washed with water, dried and concentrated under reduced pressure Recrystallization of the residue from methanol gave the desired 4-(1-(2,4'-difluoro-4-biphenylyl-)ethyl)-2-methylamino-5-thiazolecarboxylic acid (599 mg, 1.60 mmoles, yield 65%) as a white crystalline product.

Provenance & Evidence