HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 2-Amino-3-bromo-5-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 2-Amino-5-nitropyridine | HCID 77888 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Amino-3-bromo-5-nitropyridine | HCID 2734412 | 81.1% |
Reaction Steps
Bromine (62.6 mλ; 1.2 mole) was dropwise added to 2-amino-5-nitropyridine (154.1 g; 1.1 mole) in THF (300 mλ) at room temperature. The resulting mixture was stirred for one hour and then poured into water (3 λ). The crystals thus formed were recrystallized from acetonitrile (500 mλ) to give 2-amino-3-bromo-5-nitropyridine (A) (194.4 g; 80%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05260177 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-26599012638c4f07aecf33ce3718ca2c |
| Source note | uspto-grants-1993_11 |