HCID 19784284, compound → HCID 19784266, compound

Participants

Reaction Conditions

Reaction Steps

3-[3-(4-Phenyl-1-piperazinyl)propyl]-2-trifluoroacetylimino-6-trifluoromethoxybenzothiazoline hydrochloride (3.6 g), dissolved in a mixture of 7% strength aqueous potassium carbonate solution (45 cc) and methanol (150 cc), is stirred for 4 hours at a temperature in the region of 20° C. After concentration to dryness, the reaction medium is taken up in distilled water (100 cc) and the organic phase extracted with ethyl acetate (2×100 cc), dried over magnesium sulphate and concentrated to dryness under reduced pressure (20 mmHg; 2.7 kPa). After formation of the dihydrochloride by adding 4.2N ethereal hydrogen chloride (4 cc) in ethyl acetate, the precipitate is recrystallized in an absolute ethanol/ethyl ether mixture (50:50 by volume). 2-Imino-3-[3-(4-phenyl-1-piperazinyl)propyl]-6-trifluoromethoxybenzothiazoline dihydrochloride (1.6 g), m.p. 260° C., is obtained.

Provenance & Evidence