反应详情

温度

20 °C

3-{2-[4-(4-Methoxyphenyl)-1-piperazinyl]ethyl}-2-trifluoroacetylimino-6-trifluoromethoxybenzothiazoline hydrochloride (1.53 g), methanol (33 cc) and 7% strength potassium carbonate solution (21 cc) in a mixture of methanol (2 volumes) and water (5 volumes) are stirred for 4 hours at a temperature in the region of 20° C. The reaction medium is concentrated under reduced pressure and then extracted with ethereal sulphuric acid. The organic phase is dried over magnesium sulphate and then treated with an excess of alcoholic hydrochloric acid solution. The precipitate is drained, washed with ethereal sulphuric acid and dried at 50° C. at 20 mmHg. 2-Imino-3-{2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl}-6-trifluoromethoxybenzothiazoline trihydrochloride (1.05 g), m.p. 240° C., is obtained.

1. concentrationThe reaction medium is concentrated under reduced pressure
2. extractionextracted with ethereal sulphuric acid
3. dry with materialThe organic phase is dried over magnesium sulphate
4. additiontreated with an excess of alcoholic hydrochloric acid solution
5. washwashed with ethereal sulphuric acid
6. customdried at 50° C. at 20 mmHg