Bromine → 2-(5-Bromo-2-thienyl)pyridine

HRID 256844Notes

Reaction equation

HRID 256844 reaction equation
[Br:1]Br.[S:3]1[CH:7]=[CH:6][CH:5]=[C:4]1[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=1>C(Cl)Cl>[Br:1][C:7]1[S:3][C:4]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][N:9]=2)=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 768322-(2'-Thienyl)pyridine

Product 1

HCID 7364832-(5-Bromo-2-thienyl)pyridine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Bromine, 16 g (0.1 mol), was added to a solution of 8.05 g (0.05 mol) of 2-(2-thienyl)pyridine in 250 ml of methylene chloride. After stirring for 10 minutes, the reaction mixture was washed with 10% aqueous sodium carbonate solution, dried and evaporated. Crystallization from ethanol gave 9.5 g of the title compound with m.p. 85°-87°.

Workup

  1. washthe reaction mixture was washed with 10% aqueous sodium carbonate solution
  2. customdried
  3. customevaporated
  4. customCrystallization from ethanol

Sources & evidence

ORD record
ord-ade96baed20b423192878d8ef4b0e186
Source dataset
uspto-grants-1993_11
Patent number
US05260294

Reaction notes

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