HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzene, 1-bromo-3-(trifluoromethyl)- → HCID 15171848, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzene, 1-bromo-3-(trifluoromethyl)- | HCID 9817 | — |
| Reactant | rac-3,4-dihydro-2-ethynyl-2,5,7,8-tetramethyl-2H-1-benzopyran-6ol | HCID 14478563 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 15171848 | HCID 15171848 | — |
Reaction Steps
This compound was similarly prepared by reacting rac-3,4-dihydro-2-ethynyl-2,5,7,8-tetramethyl-2H-1-benzopyran-6-ol with 3-trifluoromethylbromobenzene as described in Example 26. The product was isolated by chromatography over 50 fold amount of silica gel using methylene chloride for elution. Crystallization of the combined clean fractions from petroleum ether gave colorless crystals with m.p. 81°-83°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05260294 |
| Source dataset | uspto-grants-1993_11 |
| ORD ID | ord-ac871e49156a4b2b90f45471f1f27770 |
| Source note | uspto-grants-1993_11 |