Hydrochloric Acid → benzyl (1S)-1-methyl-2-oxo-2-[(3-oxopropyl)amino]ethylcarbamate

Participants

Reaction Steps

By using an analogous procedure to that described for Reference Example 14, benzyl (1S)-2-[(3,3-diethoxypropyl)amino]-1-methyl-2-oxoethylcarbamate (2.39 g, 6.79 mmol, obtained from Reference Example 19) in tetrahydrofuran (14 ml) was reacted with 0.5 N hydrochloric acid (14 ml) for 45 minutes, to provide benzyl (1S)-1-methyl-2-oxo-2-[(3-oxopropyl)amino]ethylcarbamate (1.92 g, 100%) as a pale yellow waxy solid.

Provenance & Evidence