Methyl iodide → HCID 19075336, compound

HRID 256944Notes

Reaction equation

HRID 256944 reaction equation
[CH3:1][I:2].[CH2:3]([O:6][C:7]1[C:8]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)=[N:9][S:10][N:11]=1)[C:4]#[CH:5]>CC(C)=O>[I-:2].[CH2:3]([O:6][C:7]1[C:8]([C:12]2[CH:13]=[N+:14]([CH3:1])[CH:15]=[CH:16][CH:17]=2)=[N:9][S:10][N:11]=1)[C:4]#[CH:5]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 19075253HCID 19075253, compound

Product 1

HCID 19075336HCID 19075336, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of methyl iodide (0.45 ml, 7.2 mmol) and 3-(4-propargyloxy-1,2,5-thiadiazol-3-yl) pyridine (430 mg, 2.4 mmol) in acetone (5 ml) was stirred at room temperature for 18 h. The title compound precipitated from the solution and was collected by filtration to yield 0.58 g (67%).

Workup

  1. customThe title compound precipitated from the solution
  2. filtrationwas collected by filtration
  3. customto yield 0.58 g (67%)

Sources & evidence

ORD record
ord-91779051b0d24970a7a6d26ce210b30f
Source dataset
uspto-grants-1993_11
Patent number
US05260311

Reaction notes

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