Hydrochloric Acid → benzyl (1S)-1-benzyl-2-oxo-2-[(3-oxopropyl)amino]ethylcarbamate

Participants

Reaction Steps

By using an analogous procedure to that described for Reference Example 14, 1-benzyl-2-[(3,3-diethoxypropyl)amino]-2-oxoethylcarbamate (2.37 g, 5.54 mmol, obtained from Reference Example 21) in tetrahydrofuran (11 ml) was reacted with 0.5 N hydrochloric acid (11 ml) for 45 minutes at room temperature, to provide benzyl (1S)-1-benzyl-2-oxo-2-[(3-oxopropyl)amino]ethylcarbamate (1.84 g, 94%) as a white solid.

Provenance & Evidence